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- Title
Patients with acute coronary syndromes and elevated levels of natriuretic peptides: the results of the AVANT GARDE-TIMI 43 Trial.
- Authors
Scirica, Benjamin M; Morrow, David A; Bode, Christoph; Ruzyllo, Witold; Ruda, Mikhail; Oude Ophuis, Anthonius J M; Lopez-Sendon, Jose; Swedberg, Karl; Ogorek, Michal; Rifai, Nader; Lukashevich, Valentina; Maboudian, Mojdeh; Cannon, Christopher P; McCabe, Carolyn H; Braunwald, Eugene
- Abstract
Elevated natriuretic peptides (NPs) are associated with an increased cardiovascular risk following acute coronary syndromes (ACSs). However, the therapeutic implications are still undefined. We hypothesized that early inhibition of renin-angiotensin-aldosterone system (RAAS) in patients with preserved left ventricular function but elevated NPs but following ACS would reduce haemodynamic stress as reflected by a greater reduction NP compared with placebo.
- Publication
European heart journal, 2010, Vol 31, Issue 16, p1993
- ISSN
1522-9645
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehq190