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- Title
Interleukin 18 gene promoter polymorphism: a link between hypertension and pre-hospital sudden cardiac death: the Helsinki Sudden Death Study.
- Authors
Hernesniemi, Jussi A; Karhunen, Pekka J; Oksala, Niku; Kähönen, Mika; Levula, Mari; Rontu, Riikka; Ilveskoski, Erkki; Kajander, Olli; Goebeler, Sirkka; Viiri, Leena E; Hurme, Mikko; Lehtimäki, Terho
- Abstract
The interleukin 18 (IL-18) gene has a single nucleotide promoter region (-137) G-to-C polymorphism (rs187238) which leads to attenuated transcriptional activity of the gene and to lower production of pro-atherogenic IL-18. The C allele of this polymorphism is associated with a lower risk of sudden cardiac death (SCD). We examined the process by which this polymorphism alters the risk of SCD and coronary artery disease (CAD) by analysing the interactions between this polymorphism and environmental factors.
- Publication
European heart journal, 2009, Vol 30, Issue 23, p2939
- ISSN
1522-9645
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehp316