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- Title
Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease.
- Authors
Varenhorst, Christoph; James, Stefan; Erlinge, David; Brandt, John T; Braun, Oscar O; Man, Michael; Siegbahn, Agneta; Walker, Joseph; Wallentin, Lars; Winters, Kenneth J; Close, Sandra L
- Abstract
The metabolic pathways leading to the formation of prasugrel and clopidogrel active metabolites differ. We hypothesized that decreased CYP2C19 activity affects the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel.
- Publication
European heart journal, 2009, Vol 30, Issue 14, p1744
- ISSN
1522-9645
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehp157