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- Title
COX-1 sensitivity and thromboxane A2 production in type 1 and type 2 diabetic patients under chronic aspirin treatment.
- Authors
Pulcinelli, Fabio M; Biasucci, Luigi M; Riondino, Silvia; Giubilato, Simona; Leo, Andrea; Di Renzo, Livia; Trifirò, Elisabetta; Mattiello, Teresa; Pitocco, Dario; Liuzzo, Giovanna; Ghirlanda, Giovanni; Crea, Filippo
- Abstract
Although aspirin treatment is useful in reducing ischaemic events in diabetic patients, recent studies suggest that it is less effective when compared with non-diabetics (ND). We sought to evaluate COX-1 sensitivity and thromboxane A(2) (TxA(2)) production in type 1 (T1DM) and type 2 diabetic (T2DM) patients under chronic aspirin treatment, and also evaluate the association between thromboxane A(2) (TxA(2)) production and markers of inflammation and metabolic control, such as high-sensitivity C-reactive protein, fasting blood glucose, and haemoglobin A1c (HbA1c).
- Publication
European heart journal, 2009, Vol 30, Issue 10, p1279
- ISSN
1522-9645
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehp097