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- Title
Pacemaker current (I(f)) in the human sinoatrial node.
- Authors
Verkerk, Arie O; Wilders, Ronald; van Borren, Marcel M G J; Peters, Ron J G; Broekhuis, Eli; Lam, Kayan; Coronel, Ruben; de Bakker, Jacques M T; Tan, Hanno L
- Abstract
Animal studies revealed that the hyperpolarization-activated pacemaker current, I(f), contributes to action potential (AP) generation in sinoatrial node (SAN) and significantly determines heart rate. I(f) is becoming a novel therapy target to modulate heart rate. Yet, no studies have demonstrated that I(f) is functionally present and contributes to pacemaking in human SAN. We aimed to study I(f) properties in human SAN.
- Publication
European heart journal, 2007, Vol 28, Issue 20, p2472
- ISSN
0195-668X
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehm339