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- Title
Myocardial stiffness is an important determinant of the plasma brain natriuretic peptide concentration in patients with both diastolic and systolic heart failure.
- Authors
Watanabe, Satoshi; Shite, Junya; Takaoka, Hideyuki; Shinke, Toshiro; Imuro, Yusuke; Ozawa, Toru; Otake, Hiromasa; Matsumoto, Daisuke; Ogasawara, Daisuke; Paredes, Oscar Luis; Yokoyama, Mitsuhiro
- Abstract
Plasma brain natriuretic peptide (BNP) concentration increases in proportion to heart failure (HF) severity. Although plasma BNP decreases to a certain level by optimal treatment, there is significant heterogeneity in the baseline value among individuals. The underlying mechanism of the steady-state plasma BNP levels remains still controversial. We investigated the hypothesis that myocardial stiffness (K(m)) is a major determinant of the plasma BNP level.
- Publication
European heart journal, 2006, Vol 27, Issue 7, p832
- ISSN
0195-668X
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehi772