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- Title
Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis.
- Authors
Elesber, Ahmad A; Solomon, Hemant; Lennon, Ryan J; Mathew, Verghese; Prasad, Abhiram; Pumper, Geralyn; Nelson, Rebecca E; McConnell, Joseph P; Lerman, Lilach O; Lerman, Amir
- Abstract
Coronary endothelial dysfunction (CED) precedes atherosclerosis and is associated with cardiovascular events. Both CED and erectile dysfunction (ED) are partly mediated by impairment in the nitric oxide pathway. ED is associated with established coronary atherosclerosis, but its relationship with early coronary atherosclerosis and CED is unknown. This study was designed to test the hypothesis that CED is associated with ED in men with early coronary atherosclerosis. Moreover, the role of the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) was investigated; ADMA is a novel endogenous competitive inhibitor of nitric oxide synthase and has been shown to be an independent marker for cardiovascular disease.
- Publication
European heart journal, 2006, Vol 27, Issue 7, p824
- ISSN
0195-668X
- Publication type
Journal Article
- DOI
10.1093/eurheartj/ehi749