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Title
Opposing functions of ZEB proteins in the regulation of the TGFß/BMP signaling pathway.
Authors
Apostigo, Antonio
Abstract
Binding of TGFß/BMP factors to their receptors leads to translocation of Smad proteins to the nucleus where they activate transcription of target genes. The two-handed zinc finger proteins encoded by Zfhx1a and Zfhx1b, ZEB-1/dEF1 and ZEB-2/SIP1,