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- Title
Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism.
- Authors
Tanaka, K; Hao, Z; Kai, M; Okayama, H
- Abstract
During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.
- Publication
The EMBO journal, 2001, Vol 20, Issue 20, p5779
- ISSN
0261-4189
- Publication type
Journal Article
- DOI
10.1093/emboj/20.20.5779