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- Title
Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.
- Authors
Jäger, S; Strayle, J; Heinemeyer, W; Wolf, D H
- Abstract
In eukaryotes, the ubiquitin-proteasome system plays a major role in selective protein breakdown for cellular regulation. Here we report the discovery of a new essential component of this degradation machinery. We found the Saccharomyces cerevisiae protein Cic1 attached to 26S proteasomes playing a crucial role in substrate specificity for proteasomal destruction. Whereas degradation of short-lived test proteins is not affected, cic1 mutants stabilize the F-box proteins Cdc4 and Grr1, substrate recognition subunits of the SCF complex. Cic1 interacts in vitro and in vivo with Cdc4, suggesting a function as a new kind of substrate recruiting factor or adaptor associated with the proteasome.
- Publication
The EMBO journal, 2001, Vol 20, Issue 16, p4423
- ISSN
0261-4189
- Publication type
Journal Article
- DOI
10.1093/emboj/20.16.4423