We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis.
- Authors
Tournebize, R; Andersen, S S; Verde, F; Dorée, M; Karsenti, E; Hyman, A A
- Abstract
Assembly of a mitotic spindle requires the accurate regulation of microtubule dynamics which is accomplished, at least in part, by phosphorylation-dephosphorylation reactions. Here we have investigated the role of serine-threonine phosphatases in the control of microtubule dynamics using specific inhibitors in Xenopus egg extracts. Type 2A phosphatases are required to maintain the short steady-state length of microtubules in mitosis by regulating the level of microtubule catastrophes, in part by controlling the the microtubule-destabilizing activity and phosphorylation of Op18/stathmin. Type 1 phosphatases are only required for control of microtubule dynamics during the transitions into and out of mitosis. Thus, although both type 2A and type 1 phosphatases are involved in the regulation of microtubule dynamics, they have distinct, non-overlapping roles.
- Publication
The EMBO journal, 1997, Vol 16, Issue 18, p5537
- ISSN
0261-4189
- Publication type
Journal Article
- DOI
10.1093/emboj/16.18.5537