We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chromatin remodeling enzymes: taming the machines. Third in review series on chromatin dynamics.
- Authors
Peterson, Craig L
- Abstract
Members of the ATP-dependent family of chromatin remodeling enzymes play key roles in the regulation of transcription, development, DNA repair and cell cycle. Each of these enzymes are multi-subunit assemblies that hydrolyze thousands of molecules of ATP in order to change nucleosome positions, disrupt DNA-histone interactions and perhaps destabilize chromatin folding. Here I review recent studies that suggest these potent machines can be 'tamed' by one of several mechanisms: targeting their activity to localized regions, blocking their chromatin binding activity or inhibiting their remodeling activity.
- Publication
EMBO reports, 2002, Vol 3, Issue 4, p319
- ISSN
1469-221X
- Publication type
Journal Article
- DOI
10.1093/embo-reports/kvf075