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- Title
Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription.
- Authors
Karetsou, Zoe; Kretsovali, Adroniki; Murphy, Carol; Tsolas, Orestes; Papamarcaki, Thomais
- Abstract
Prothymosin alpha (ProTalpha) is a histone H1-binding protein localized in sites of active transcription in the nucleus. We report here that ProTalpha physically interacts with the CREB-binding protein (CBP), which is a versatile transcription co-activator. Confocal laser scanning microscopy reveals that ProTalpha partially colocalizes with CBP in discrete subnuclear domains. Using transient transfections, we show that ProTalpha synergizes with CBP and stimulates AP1- and NF-kappaB-dependent transcription. Furthermore, overexpression of ProTalpha enhances the transactivation potential of CBP. These findings reveal a new function for ProTalpha in transcription activation, probably through CBP-mediated recruitment to different promoters.
- Publication
EMBO reports, 2002, Vol 3, Issue 4, p361
- ISSN
1469-221X
- Publication type
Journal Article
- DOI
10.1093/embo-reports/kvf071