We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Myocardium at risk can be determined by ex vivo T2-weighted magnetic resonance imaging even in the presence of gadolinium: comparison to myocardial perfusion single photon emission computed tomography.
- Authors
Ubachs, Joey F A; Engblom, Henrik; Koul, Sasha; Kanski, Mikael; Andersson, Patrik; van der Pals, Jesper; Carlsson, Marcus; Erlinge, David; Arheden, Håkan
- Abstract
Determination of the myocardium at risk (MaR) and final infarct size by cardiac magnetic resonance imaging (CMR) enables calculation of salvaged myocardium in acute infarction. T2-weighted imaging is performed prior to the administration of gadolinium, since gadolinium affects T2 tissue properties. This is, however, difficult in an ex vivo model since gadolinium must be administered for determination of infarct size by CMR. We aimed to test the ability of ex vivo T2-weighted imaging to assess MaR using myocardial perfusion single photon emission computed tomography (SPECT) as reference and to investigate whether MaR could be assessed by ex vivo T2-weighted imaging after injection of gadolinium. Materials and methods In 18 domestic pigs, the left anterior descending artery was occluded for either 30 or 40 min, followed by 4 h of reperfusion. After explantation of the hearts, myocardial perfusion SPECT and T2-weighted imaging were performed for determination of MaR, either with or without gadolinium. Infarct size was determined by T1-weighted imaging and by triphenyl tetrazolium chloride (TTC) staining.
- Publication
European heart journal. Cardiovascular Imaging, 2013, Vol 14, Issue 3, p261
- ISSN
2047-2412
- Publication type
Journal Article
- DOI
10.1093/ehjci/jes142