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- Title
A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.
- Authors
Aiba, H; Baba, T; Hayashi, K; Inada, T; Isono, K; Itoh, T; Kasai, H; Kashimoto, K; Kimura, S; Kitakawa, M; Kitagawa, M; Makino, K; Miki, T; Mizobuchi, K; Mori, H; Mori, T; Motomura, K; Nakade, S; Nakamura, Y; Nashimoto, H; Nishio, Y; Oshima, T; Saito, N; Sampei, G; Horiuchi, T
- Abstract
The 569,750 base pair sequence corresponding to the 28.0-40.1 min region on the genetic map of Escherichia coli K-12 (W3110) was determined. This region includes the replication terminus region and contained at least 549 potential open reading frames. Among them, 160 (29%) were previously reported, 174 (32%) were homologous to other known genes, 102 (18%) were identical or similar to hypothetical genes registered in databases, and the remaining 113 (21%) did not show a significant similarity to any other gene. Of interest was the finding of a large number of genes and gene clusters in and near the replication termination region which had been thought to be genetically silent. Those included a cluster of genes for fatty acid beta-oxidation, the third copy of the pot (spermidine/putrescine transport system) gene cluster, the second dpp (dipeptide transport system) operon, the second dsm (anaerobic dimethyl sulfoxide reductase) operon, a cluster of fim (fimbrial) genes and a DNA helicase-like gene with a high molecular weight. In addition, we found the dnaC- and dnaT-like genes in the cryptic prophage, Rac, and a number of genes originated probably from plasmids.
- Publication
DNA research : an international journal for rapid publication of reports on genes and genomes, 1996, Vol 3, Issue 6, p363
- ISSN
1340-2838
- Publication type
Journal Article
- DOI
10.1093/dnares/3.6.363