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- Title
Brahma-related gene 1 (Brg1) epigenetically regulates CAM activation during hypoxic pulmonary hypertension.
- Authors
Chen, Dewei; Fang, Fei; Yang, Yuyu; Chen, Jian; Xu, Gang; Xu, Yong; Gao, Yuqi
- Abstract
Establishment of an inflammatory milieu following elevated leukocyte adhesion to the vascular endothelium, which is mediated by transcriptional activation of cell adhesion molecules (CAMs), contributes to the pathogenesis of chronic hypoxia-induced pulmonary hypertension (HPH). The epigenetic switch that dictates CAM transactivation in response to hypoxia in endothelial cells leading up to HPH is not fully appreciated.
- Publication
Cardiovascular research, 2013, Vol 100, Issue 3, p363
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvt214