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- Title
PRSS23 is essential for the Snail-dependent endothelial-to-mesenchymal transition during valvulogenesis in zebrafish.
- Authors
Chen, I-Hui; Wang, Hsueh-Hsiao; Hsieh, Yi-Shan; Huang, Wei-Chang; Yeh, Hung-I; Chuang, Yung-Jen
- Abstract
Cardiac valve disease is a common cause of congenital heart failure. Cardiac valve development requires a complex regulation of assorted protease activities. Nevertheless, the regulation of these proteases during atrioventricular (AV) valve formation is poorly understood. Previously, PRSS23, a novel vascular protease, is shown to be highly expressed at the AV canal during murine heart development; however, its function remains unknown. In this study, we sought to characterize the functional role of PRSS23 during cardiac valve formation.
- Publication
Cardiovascular research, 2013, Vol 97, Issue 3, p443
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvs355