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Title
Chronic potentiation of cardiac L-type Ca(2+) channels by pirfenidone.
Authors
Ramos-Mondragón, Roberto; Galindo, Carlos A; García-Castañeda, Maricela; Sánchez-Vargas, José L; Vega, Ana V; Gómez-Viquez, Norma L; Avila, Guillermo
Abstract
On the basis of its ability to inhibit fibrosis, pirfenidone has drawn the attention as an intriguing candidate for treating cardiac disease. However, its precise electrophysiological effects have yet to be elucidated. Here, we have investigated its potential to modulate ion channels.