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- Title
HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis.
- Authors
Madrigal-Matute, Julio; Fernandez-Garcia, Carlos Ernesto; Gomez-Guerrero, Carmen; Lopez-Franco, Oscar; Muñoz-Garcia, Begoña; Egido, Jesus; Blanco-Colio, Luis Miguel; Martin-Ventura, Jose Luis
- Abstract
Reactive oxygen species (ROS) participate in atherogenesis through different mechanisms including oxidative stress and inflammation. Proteins implicated in both processes, such as mitogen-activated protein kinase kinase (MEK) and some NADPH oxidase (NOX) subunits, are heat shock protein-90 (HSP90) client proteins. In this work, we investigated the antioxidant properties of the HSP90 inhibitor, 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in experimental atherosclerosis.
- Publication
Cardiovascular research, 2012, Vol 95, Issue 1, p116
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvs158