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- Title
Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells.
- Authors
Sarkar, Kakali; Rey, Sergio; Zhang, Xianjie; Sebastian, Raul; Marti, Guy P; Fox-Talbot, Karen; Cardona, Amanda V; Du, Junkai; Tan, Yee Sun; Liu, Lixin; Lay, Frank; Gonzalez, Frank J; Harmon, John W; Semenza, Gregg L
- Abstract
Hypoxia-inducible factor 1 (HIF-1) is a heterodimer composed of HIF-1α and HIF-1β subunits. HIF-1 is known to promote tissue vascularization by activating the transcription of genes encoding angiogenic factors, which bind to receptors on endothelial cells (ECs) and bone marrow-derived angiogenic cells (BMDACs). In this study, we analysed whether HIF-1 activity in the responding ECs and BMDACs is also required for cutaneous vascularization during burn wound healing.
- Publication
Cardiovascular research, 2012, Vol 93, Issue 1, p162
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvr282