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- Title
A phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells.
- Authors
Hunter, Irene; Mascall, Keith S; Ramos, Joe W; Nixon, Graeme F
- Abstract
Growth factor-induced repression of smooth muscle (SM) cell marker genes is an integral part of vascular SM (VSM) cell proliferation. This is partly regulated via translocation of extracellular signal-regulated kinase 1/2 (ERK1/2) to the nucleus which activates the transcription factor Elk-1. The mediators involved in ERK1/2 nuclear translocation in VSM cells are unknown. The aim of this study is to examine the mechanisms which regulate growth factor-induced nuclear translocation of ERK1/2 and gene expression in VSM cells.
- Publication
Cardiovascular research, 2011, Vol 90, Issue 3, p557
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvr039