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- Title
Parathyroid hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4(+) stem cells into the ischaemic heart.
- Authors
Huber, Bruno C; Brunner, Stefan; Segeth, Alexander; Nathan, Petra; Fischer, Rebekka; Zaruba, Marc M; Vallaster, Marcus; Theiss, Hans D; David, Robert; Gerbitz, Armin; Franz, Wolfgang-Michael
- Abstract
Parathyroid hormone (PTH) has been shown to promote stem cell mobilization into peripheral blood. Moreover, PTH treatment after myocardial infarction (MI) improved survival and myocardial function associated with enhanced homing of bone marrow-derived stem cells (BMCs). To unravel the molecular mechanisms of PTH-mediated stem cell trafficking, we analysed wild-type (wt) and green fluorescent protein (GFP)-transgenic mice after MI with respect to the pivotal stromal cell-derived factor-1 (SDF-1)/chemokine receptor type 4 (CXCR4) axis.
- Publication
Cardiovascular research, 2011, Vol 90, Issue 3, p529
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvr014