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- Title
Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblasts.
- Authors
Verma, Suresh K; Lal, Hind; Golden, Honey B; Gerilechaogetu, Fnu; Smith, Manuela; Guleria, Rakeshwar S; Foster, Donald M; Lu, Guangrong; Dostal, David E
- Abstract
Angiotensin II (Ang II) stimulates cardiac remodelling and fibrosis in the mechanically overloaded myocardium. Although Rho GTPases regulate several cellular processes, including myocardial remodelling, involvement in mediating mechanical stretch-induced regulation of angiotensinogen (Ao), the precursor to Ang II, remains to be determined. We, therefore, examined the role and associated signalling mechanisms of Rho GTPases (Rac1 and RhoA) in regulation of Ao gene expression in a stretch model of neonatal rat cardiac fibroblasts (CFs).
- Publication
Cardiovascular research, 2011, Vol 90, Issue 1, p88
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvq385