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- Title
Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction.
- Authors
Haas, Michael S; Alicot, Elisabeth M; Schuerpf, Franziska; Chiu, Isaac; Li, Jinan; Moore, Francis D; Carroll, Michael C
- Abstract
Coronary artery occlusion resulting in ischaemia/reperfusion (I/R) injury is a major cause of mortality in the western world. Circulating natural IgM has been shown to play a significant role in reperfusion injury, leading to the notion of a pathogenic response against self by the innate immune system. A specific self-antigen (non-muscle myosin heavy chain II) was recently identified as the major target of pathogenic natural IgM. Therefore, we hypothesized that a synthetic peptide mimetope (N2) or monoclonal antibodies directed against the self-antigen would prevent specific IgM binding to the self-antigen and reduce reperfusion injury in the heart.
- Publication
Cardiovascular research, 2010, Vol 87, Issue 4, p618
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvq141