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- Title
Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts.
- Authors
Roy, Sashwati; Khanna, Savita; Azad, Ali; Schnitt, Rebecca; He, Guanglong; Weigert, Cora; Ichijo, Hidenori; Sen, Chandan K
- Abstract
In the ischaemia-reperfused heart, transforming growth factor beta (TGFbeta) proteins trigger the differentiation of cardiac fibroblasts (CFs) contributing to fibrosis. Reoxygenation of the heart, in addition to being a trigger for reperfusion injury, induces tissue remodelling by hyperoxia-sensitive signalling processes involving TGFbeta. Here, we sought to characterize the molecular mechanisms responsible for the O(2)-sensitive transcriptional induction of TGFbeta in murine CF and to test the significance of such findings in the infarcted myocardium in vivo using laser capture microdissection.
- Publication
Cardiovascular research, 2010, Vol 87, Issue 4, p647
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvq123