We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.
- Authors
Rey, Sergio; Semenza, Gregg L
- Abstract
The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.
- Publication
Cardiovascular research, 2010, Vol 86, Issue 2, p236
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvq045