Your institution may have access to this item. Find your institution then sign in to continue.
Title
Connexin43 knockdown or overexpression modulates cell coupling in control and failing rabbit left ventricular myocytes.
Authors
Xun Ai; Weiwei Zhao; Pogwizd, Steven M.
Abstract
Aims: We have shown that failing human and rabbit left ventricle (LV) exhibits downregulation and dephosphorylation of connexin43 (Cx43) and that Cx43 dephosphorylation in heart failure (HF) contributes to reduced cell coupling. However, the role of Cx43 downregulation per se in impaired coupling in HF is unclear.