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- Title
Protein kinase C delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis.
- Authors
Yamanouchi, Dai; Kato, Kaori; Ryer, Evan J; Zhang, Fan; Liu, Bo
- Abstract
A balance between apoptosis and proliferation of vascular smooth muscle cells (VSMC) influences the development of intimal hyperplasia. We have previously demonstrated that protein kinase C delta (PKCdelta) regulates both apoptosis and proliferation of VSMC in vitro. Here we investigate the role of PKCdelta in intimal hyperplasia through gene deletion or overexpression in rodent models of arterial injury.
- Publication
Cardiovascular research, 2010, Vol 85, Issue 3, p434
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvp328