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- Title
Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion.
- Authors
Rudolph, Volker; Rudolph, Tanja K; Schopfer, Francisco J; Bonacci, Gustavo; Woodcock, Steven R; Cole, Marsha P; Baker, Paul R S; Ramani, Ravi; Freeman, Bruce A
- Abstract
Nitrated fatty acids (NO(2)-FA) have been identified as endogenous anti-inflammatory signalling mediators generated by oxidative inflammatory reactions. Herein the in vivo generation of nitro-oleic acid (OA-NO(2)) and nitro-linoleic acid (LNO(2)) was measured in a murine model of myocardial ischaemia and reperfusion (I/R) and the effect of exogenous administration of OA-NO(2) on I/R injury was evaluated.
- Publication
Cardiovascular research, 2010, Vol 85, Issue 1, p155
- ISSN
1755-3245
- Publication type
Journal Article
- DOI
10.1093/cvr/cvp275