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- Title
Cross-talk between cytokines and renin–angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-κB.
- Authors
Yu-Ming Kang; Ying Ma; Carrie Elks; Jin-Ping Zheng; Zhi-Ming Yang; Francis, Joseph
- Abstract
Aims: Nuclear factor-kappa B (NF-κB) is a potent inducer of pro-inflammatory cytokines (PIC) and oxidative stress in cardiovascular disease. In this study, we determined whether upregulation of NF-κB in the hypothalamic paraventricular nucleus (PVN) contributed to neurohumoral excitation either directly, or via interaction with the renin–angiotensin system (RAS), in heart failure (HF).
- Publication
Cardiovascular Research, 2008, Vol 79, Issue 4, p671
- ISSN
0008-6363
- Publication type
Academic Journal
- DOI
10.1093/cvr/cvn119