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- Title
LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet.
- Authors
Hu, Changping; Dandapat, Abhijit; Sun, Liuqin; Chen, Jiawei; Marwali, Muhammad R; Romeo, Francesco; Sawamura, Tatsuya; Mehta, Jawahar L
- Abstract
Collagen, as a component of the extracellular matrix, has been linked to atherosclerotic plaque formation and stability. Activation of LOX-1, a lectin-like oxidized low-density lipoprotein (LDL) receptor-1, exerts a significant role in collagen formation. We examine the hypothesis that LOX-1 deletion may inhibit collagen accumulation in atherosclerotic arteries in LDL receptor (LDLR) knockout (KO) mice.
- Publication
Cardiovascular research, 2008, Vol 79, Issue 2, p287
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1093/cvr/cvn110