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- Title
Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities.
- Authors
Ki Won Lee; Nam Joo Kang; Min-Ho Oak; Mun Kyung Hwang; Jong Hun Kim; Schini-Kerth, Valérie B.; Hyong Joo Lee
- Abstract
Aims: Expression and activation of matrix metalloproteinase (MMP)-2 play pivotal roles in the migration and invasion of human aortic vascular smooth muscle cells (VSMC) originating from normal human tissue, which is strongly linked to atherosclerosis. The present study investigated the possible inhibitory effects of cocoa procyanidin on thrombin-induced expression and activation of MMP-2 in VSMC.
- Publication
Cardiovascular Research, 2008, Vol 79, Issue 1, p34
- ISSN
0008-6363
- Publication type
Academic Journal
- DOI
10.1093/cvr/cvn056