We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans.
- Authors
Lillie, Patrick J; Berthoud, Tamara K; Powell, Timothy J; Lambe, Teresa; Mullarkey, Caitlin; Spencer, Alexandra J; Hamill, Matthew; Peng, Yanchun; Blais, Marie-Eve; Duncan, Christopher J A; Sheehy, Susanne H; Havelock, Tom; Faust, Saul N; Williams, Rob Lambkin; Gilbert, Anthony; Oxford, John; Dong, Tao; Hill, Adrian V S; Gilbert, Sarah C
- Abstract
The novel influenza vaccine MVA-NP+M1 is designed to boost cross-reactive T-cell responses to internal antigens of the influenza A virus that are conserved across all subtypes, providing protection against both influenza disease and virus shedding against all influenza A viruses. Following a phase 1 clinical study that demonstrated vaccine safety and immunogenicity, a phase 2a vaccination and influenza challenge study has been conducted in healthy adult volunteers.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012, Vol 55, Issue 1, p19
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1093/cid/cis327