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- Title
Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV?
- Authors
Justice, Amy C; Freiberg, Matthew S; Tracy, Russ; Kuller, Lew; Tate, Janet P; Goetz, Matthew Bidwell; Fiellin, David A; Vanasse, Gary J; Butt, Adeel A; Rodriguez-Barradas, Maria C; Gibert, Cynthia; Oursler, Kris Ann; Deeks, Steven G; Bryant, Kendall; VACS Project Team
- Abstract
When added to age, CD4 count and human immunodeficiency virus type 1 (HIV-1) RNA alone (Restricted Index), hemoglobin, FIB-4 Index, hepatitis C virus (HCV), and estimated glomerular filtration rate improve prediction of mortality. Weighted and combined, these 7 routine clinical variables constitute the Veterans Aging Cohort Study (VACS) Index. Because nonroutine biomarkers of inflammation (interleukin 6 [IL-6]), coagulation (D-dimer), and monocyte activation (sCD14) also predict mortality, we test the association of these indices and biomarkers with each other and with mortality.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012, Vol 54, Issue 7, p984
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1093/cid/cir989