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- Title
Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.
- Authors
Berthoud, Tamara K; Hamill, Matthew; Lillie, Patrick J; Hwenda, Lenias; Collins, Katharine A; Ewer, Katie J; Milicic, Anita; Poyntz, Hazel C; Lambe, Teresa; Fletcher, Helen A; Hill, Adrian V S; Gilbert, Sarah C
- Abstract
Influenza A viruses cause occasional pandemics and frequent epidemics. Licensed influenza vaccines that induce high antibody titers to the highly polymorphic viral surface antigen hemagglutinin must be re-formulated and readministered annually. A vaccine providing protective immunity to the highly conserved internal antigens could provide longer-lasting protection against multiple influenza subtypes.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011, Vol 52, Issue 1, p1
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1093/cid/ciq015