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- Title
The resting brain: unconstrained yet reliable.
- Authors
Shehzad, Zarrar; Kelly, A M Clare; Reiss, Philip T; Gee, Dylan G; Gotimer, Kristin; Uddin, Lucina Q; Lee, Sang Han; Margulies, Daniel S; Roy, Amy Krain; Biswal, Bharat B; Petkova, Eva; Castellanos, F Xavier; Milham, Michael P
- Abstract
Recent years have witnessed an upsurge in the usage of resting-state functional magnetic resonance imaging (fMRI) to examine functional connectivity (fcMRI), both in normal and pathological populations. Despite this increasing popularity, concerns about the psychologically unconstrained nature of the "resting-state" remain. Across studies, the patterns of functional connectivity detected are remarkably consistent. However, the test-retest reliability for measures of resting state fcMRI measures has not been determined. Here, we quantify the test-retest reliability, using resting scans from 26 participants at 3 different time points. Specifically, we assessed intersession (>5 months apart), intrasession (<1 h apart), and multiscan (across all 3 scans) reliability and consistency for both region-of-interest and voxel-wise analyses. For both approaches, we observed modest to high reliability across connections, dependent upon 3 predictive factors: 1) correlation significance (significantly nonzero > nonsignificant), 2) correlation valence (positive > negative), and 3) network membership (default mode > task positive network). Short- and long-term measures of the consistency of global connectivity patterns were highly robust. Finally, hierarchical clustering solutions were highly reproducible, both across participants and sessions. Our findings provide a solid foundation for continued examination of resting state fcMRI in typical and atypical populations.
- Publication
Cerebral cortex (New York, N.Y. : 1991), 2009, Vol 19, Issue 10, p2209
- ISSN
1460-2199
- Publication type
Journal Article
- DOI
10.1093/cercor/bhn256