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- Title
Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes.
- Authors
Yang, Hannah P; Gonzalez Bosquet, Jesus; Li, Qizhai; Platz, Elizabeth A; Brinton, Louise A; Sherman, Mark E; Lacey, James V, Jr; Gaudet, Mia M; Burdette, Laurie A; Figueroa, Jonine D; Ciampa, Julia G; Lissowska, Jolanta; Peplonska, Beata; Chanock, Stephen J; Garcia-Closas, Montserrat
- Abstract
Estrogen plays a major role in endometrial carcinogenesis, suggesting that common variants of genes in the sex hormone metabolic pathway may be related to endometrial cancer risk. In support of this view, variants in CYP19A1 [cytochrome P450 (CYP), family 19, subfamily A, polypeptide 1] have been associated with both circulating estrogen levels and endometrial cancer risk. Associations with variants in other genes have been suggested, but findings have been inconsistent.
- Publication
Carcinogenesis, 2010, Vol 31, Issue 5, p827
- ISSN
1460-2180
- Publication type
Journal Article
- DOI
10.1093/carcin/bgp328