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- Title
Therapeutic approaches to Alzheimer's disease.
- Authors
Hans-Wolfgang Klafki; Matthias Staufenbiel; Johannes Kornhuber; Jens Wiltfang
- Abstract
Alzheimer's disease is an age-related progressive neurodegenerative disorder with an enormous unmet medical need. It is the most common form of dementia affecting ∼5% of adults over 65 years. In view of our ageing society the number of patients, as well as the economical and social impact, is expected to grow dramatically in the future. Currently available medications appear to be able to produce moderate symptomatic benefits but not to stop disease progression. The search for novel therapeutic approaches targeting the presumed underlying pathogenic mechanisms has been a major focus of research and it is expected that novel medications with disease-modifying properties will emerge from these efforts in the future. In this review, currently available drugs as well as novel therapeutic strategies, in particular those targeting amyloid and tau pathologies, are discussed.
- Publication
Brain: A Journal of Neurology, 2006, Vol 129, Issue 11, p2840
- ISSN
0006-8950
- Publication type
Academic Journal
- DOI
10.1093/brain/awl280