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- Title
A clinicopathological study of autism.
- Authors
Bailey, A; Luthert, P; Dean, A; Harding, B; Janota, I; Montgomery, M; Rutter, M; Lantos, P
- Abstract
A neuropathological study of autism was established and brain tissue examined from six mentally handicapped subjects with autism. Clinical and educational records were obtained and standardized diagnostic interviews conducted with the parents of cases not seen before death. Four of the six brains were megalencephalic, and areas of cortical abnormality were identified in four cases. There were also developmental abnormalities of the brainstem, particularly of the inferior olives. Purkinje cell number was reduced in all the adult cases, and this reduction was sometimes accompanied by gliosis. The findings do not support previous claims of localized neurodevelopmental abnormalities. They do point to the likely involvement of the cerebral cortex in autism.
- Publication
Brain : a journal of neurology, 1998, Vol 121 ( Pt 5), p889
- ISSN
0006-8950
- Publication type
Journal Article
- DOI
10.1093/brain/121.5.889