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- Title
Regulation of pentraxin-3 by antioxidants.
- Authors
Hill, A L; Lowes, D A; Webster, N R; Sheth, C C; Gow, N A R; Galley, H F
- Abstract
Pentraxin-3 (PTX3) may be a useful biomarker in sepsis, but its regulatory mechanisms are still unclear. Oxidative stress is well defined in patients with sepsis and has a role in regulation of inflammatory pathways which may include PTX3. We undertook an in vitro study of the effect of antioxidants on regulation of PTX3 in endothelial cells combined with a prospective observational pilot study of PTX3 in relation to markers of antioxidant capacity and oxidative stress in patients with sepsis.
- Publication
British journal of anaesthesia, 2009, Vol 103, Issue 6, p833
- ISSN
1471-6771
- Publication type
Journal Article
- DOI
10.1093/bja/aep298