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- Title
Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers.
- Authors
Chizh, B A; Göhring, M; Tröster, A; Quartey, G K; Schmelz, M; Koppert, W
- Abstract
Central sensitization is an important mechanism of neuropathic pain; its human models could be useful for early detection of efficacy of novel treatments. The electrical hyperalgesia model invokes central sensitization by repetitive stimulation of the skin. To assess its predictive value, we have investigated pregabalin, a standard neuropathic pain treatment, and aprepitant, an NK(1) antagonist, as an example of a drug class active in animal models but not in neuropathic pain patients. Furthermore, we explored if combinations of either of these drugs with the COX-2 inhibitor parecoxib could improve its efficacy.
- Publication
British journal of anaesthesia, 2007, Vol 98, Issue 2, p246
- ISSN
0007-0912
- Publication type
Journal Article
- DOI
10.1093/bja/ael344