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- Title
Shimmer: detection of genetic alterations in tumors using next-generation sequence data.
- Authors
Hansen, Nancy F; Gartner, Jared J; Mei, Lan; Samuels, Yardena; Mullikin, James C
- Abstract
Extensive DNA sequencing of tumor and matched normal samples using exome and whole-genome sequencing technologies has enabled the discovery of recurrent genetic alterations in cancer cells, but variability in stromal contamination and subclonal heterogeneity still present a severe challenge to available detection algorithms.
- Publication
Bioinformatics (Oxford, England), 2013, Vol 29, Issue 12, p1498
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btt183