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- Title
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data.
- Authors
Teschendorff, Andrew E; Marabita, Francesco; Lechner, Matthias; Bartlett, Thomas; Tegner, Jesper; Gomez-Cabrero, David; Beck, Stephan
- Abstract
The Illumina Infinium 450 k DNA Methylation Beadchip is a prime candidate technology for Epigenome-Wide Association Studies (EWAS). However, a difficulty associated with these beadarrays is that probes come in two different designs, characterized by widely different DNA methylation distributions and dynamic range, which may bias downstream analyses. A key statistical issue is therefore how best to adjust for the two different probe designs.
- Publication
Bioinformatics (Oxford, England), 2013, Vol 29, Issue 2, p189
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts680