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- Title
Site identification in high-throughput RNA-protein interaction data.
- Authors
Uren, Philip J; Bahrami-Samani, Emad; Burns, Suzanne C; Qiao, Mei; Karginov, Fedor V; Hodges, Emily; Hannon, Gregory J; Sanford, Jeremy R; Penalva, Luiz O F; Smith, Andrew D
- Abstract
Post-transcriptional and co-transcriptional regulation is a crucial link between genotype and phenotype. The central players are the RNA-binding proteins, and experimental technologies [such as cross-linking with immunoprecipitation- (CLIP-) and RIP-seq] for probing their activities have advanced rapidly over the course of the past decade. Statistically robust, flexible computational methods for binding site identification from high-throughput immunoprecipitation assays are largely lacking however.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 23, p3013
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts569