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- Title
GFOLD: a generalized fold change for ranking differentially expressed genes from RNA-seq data.
- Authors
Feng, Jianxing; Meyer, Clifford A; Wang, Qian; Liu, Jun S; Shirley Liu, X; Zhang, Yong
- Abstract
RNA-seq has been widely used in transcriptome analysis to effectively measure gene expression levels. Although sequencing costs are rapidly decreasing, almost 70% of all the human RNA-seq samples in the gene expression omnibus do not have biological replicates and more unreplicated RNA-seq data were published than replicated RNA-seq data in 2011. Despite the large amount of single replicate studies, there is currently no satisfactory method for detecting differentially expressed genes when only a single biological replicate is available.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 21, p2782
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts515