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- Title
Bayesian inference of signaling network topology in a cancer cell line.
- Authors
Hill, Steven M; Lu, Yiling; Molina, Jennifer; Heiser, Laura M; Spellman, Paul T; Speed, Terence P; Gray, Joe W; Mills, Gordon B; Mukherjee, Sach
- Abstract
Protein signaling networks play a key role in cellular function, and their dysregulation is central to many diseases, including cancer. To shed light on signaling network topology in specific contexts, such as cancer, requires interrogation of multiple proteins through time and statistical approaches to make inferences regarding network structure.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 21, p2804
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts514