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- Title
Telescoper: de novo assembly of highly repetitive regions.
- Authors
Bresler, Ma'ayan; Sheehan, Sara; Chan, Andrew H; Song, Yun S
- Abstract
With advances in sequencing technology, it has become faster and cheaper to obtain short-read data from which to assemble genomes. Although there has been considerable progress in the field of genome assembly, producing high-quality de novo assemblies from short-reads remains challenging, primarily because of the complex repeat structures found in the genomes of most higher organisms. The telomeric regions of many genomes are particularly difficult to assemble, though much could be gained from the study of these regions, as their evolution has not been fully characterized and they have been linked to aging.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 18, pi311
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts399