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- Title
EnrichNet: network-based gene set enrichment analysis.
- Authors
Glaab, Enrico; Baudot, Anaïs; Krasnogor, Natalio; Schneider, Reinhard; Valencia, Alfonso
- Abstract
Assessing functional associations between an experimentally derived gene or protein set of interest and a database of known gene/protein sets is a common task in the analysis of large-scale functional genomics data. For this purpose, a frequently used approach is to apply an over-representation-based enrichment analysis. However, this approach has four drawbacks: (i) it can only score functional associations of overlapping gene/proteins sets; (ii) it disregards genes with missing annotations; (iii) it does not take into account the network structure of physical interactions between the gene/protein sets of interest and (iv) tissue-specific gene/protein set associations cannot be recognized.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 18, pi451
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts389