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- Title
PurityEst: estimating purity of human tumor samples using next-generation sequencing data.
- Authors
Su, Xiaoping; Zhang, Li; Zhang, Jianping; Meric-Bernstam, Funda; Weinstein, John N
- Abstract
We developed a novel algorithm, PurityEst, to infer the tumor purity level from the allelic differential representation of heterozygous loci with somatic mutations in a human tumor sample with a matched normal tissue using next-generation sequencing data. We applied our tool to a whole cancer genome sequencing datasets and demonstrated the accuracy of PurityEst compared with DNA copy number-based estimation.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 17, p2265
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts365