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- Title
Ancestral haplotype-based association mapping with generalized linear mixed models accounting for stratification.
- Authors
Zhang, Z; Guillaume, F; Sartelet, A; Charlier, C; Georges, M; Farnir, F; Druet, T
- Abstract
In many situations, genome-wide association studies are performed in populations presenting stratification. Mixed models including a kinship matrix accounting for genetic relatedness among individuals have been shown to correct for population and/or family structure. Here we extend this methodology to generalized linear mixed models which properly model data under various distributions. In addition we perform association with ancestral haplotypes inferred using a hidden Markov model.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 19, p2467
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts348